The Boy in the Plastic Bubble (1976)

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Based on a true story, Tod Lubitch is born with a deficient immune system (which is unlike being born with AIDS). As such, he must spend the rest of his life in a completely sterile environment. His room is completely hermetically sealed against bacteria and virus, his food is specially prepared, and his only human contact comes in the form of gloved hands. The movie follows his life into a teenager.

Director: Randal Kleiser

Writers: Douglas Day Stewart (teleplay), Joe Morgenstern (story) (as Joseph Morgenstern) 

Stars: John Travolta, Glynnis O'Connor, Robert Reed